S. Carolina vs. UK Football Prediction & Odds - Sept. 27

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The South Carolina Gamecocks (2-2) square off against a fellow SEC opponent when they host the Kentucky Wildcats (2-1) on Saturday, September 27, 2025 at Williams-Brice Stadium.

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South Carolina vs. Kentucky Matchup Info

  • Game date: Saturday, September 27, 2025
  • Game time: 7:45 p.m. ET
  • Location: Columbia, South Carolina
  • Venue: Williams-Brice Stadium
  • TV channel: SEC Network
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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South Carolina vs. Kentucky Odds and Prediction

  • Spread favorite: Gamecocks (-5.5)
  • Moneyline: Gamecocks (-221), Wildcats (+181)
  • Total: 47.5 points
  • Pick ATS: Kentucky (+5.5)
  • Pick OU: Over (47.5)
  • Prediction: South Carolina 24, Kentucky 23

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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South Carolina vs. Kentucky Betting Records and Insights

  • South Carolina has won two games against the spread this season.
  • Kentucky has won one game against the spread this season.
  • The Gamecocks have been favored by 5.5 points or more two times this season, and covered the spread in one of those contests.
  • The Wildcats have won their only game this season when playing as at least 5.5-point underdogs.
  • Games featuring South Carolina have gone over the point total just once this season.
  • Kentucky games have hit the over twice this year.

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