The No. 19 Louisville Cardinals (7-2) host an ACC battle against the Clemson Tigers (4-5) on Friday, November 14, 2025 at L&N Federal Credit Union Stadium.
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Louisville vs. Clemson Matchup Info
- Game date: Friday, November 14, 2025
- Game time: 7:30 p.m. ET
- Location: Louisville, Kentucky
- Venue: L&N Federal Credit Union Stadium
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Louisville vs. Clemson Odds and Prediction
- Spread favorite: Cardinals (-2.5)
- Moneyline: Cardinals (-130), Tigers (+110)
- Total: 50.5 points
- Pick ATS: Louisville (-2.5)
- Pick OU: Over (50.5)
- Prediction: Louisville 31, Clemson 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Louisville vs. Clemson Betting Records and Insights
- Louisville has compiled a 3-6-0 ATS record so far this year.
- Clemson has won three games against the spread this season, failing to cover six times.
- The Cardinals have covered the spread twice when favored by 2.5 points or more this season (in eight opportunities).
- In Louisville's nine games this season, the combined scoring has gone over the point total five times.
- In 2025, four Clemson games have gone over the point total.