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The Louisville Cardinals (7-2) will host the South Carolina Gamecocks (7-1) after winning three straight home games.
Thursday's matchup between the Gamecocks and the Cardinals features the Gamecocks as double-digit 14.5-point favorites. The game's point total is 139.5.
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South Carolina vs. Louisville Odds and Game Info
- Game day: Thursday, December 4, 2025
- Game time: 7 p.m. ET
- TV channel: ESPN
- Location: Louisville, Kentucky
- Arena: KFC Yum! Center
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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South Carolina vs. Louisville Odds and Prediction
- Spread favorite: South Carolina (-14.5)
- Moneyline: South Carolina (-1351), Louisville (+800)
- Total: 139.5 points
Pick ATS:Louisville (+14.5)
- Pick OU: Over (139.5)
- Prediction: South Carolina 74, Louisville 67
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South Carolina vs. Louisville Comparison
| South Carolina Rank | South Carolina Stat | Louisville Stat | Louisville Rank | |
|---|---|---|---|---|
| 9th | 89.5 | Points Scored | 81.2 | 28th |
| 24th | 53.4 | Points Allowed | 56.4 | 56th |
| 14th | 19.8 | Assists | 16.4 | 49th |
| 15th | 11.6 | Turnovers | 10.9 | 9th |
| 4th | 53.7% | Field Goal % | 45.9% | 49th |
| 1st | 30.1% | Field Goal % Allowed | 38.4% | 146th |
South Carolina Key Players
- The scoring leader for the Gamecocks this season is Joyce Edwards, who averages 19.6 points, 5.8 rebounds, and 2.9 assists per game.
- Madina Okot leads South Carolina in rebounding, averaging 11.1 per game, while Raven Johnson leads the team in assists, distributing an average of 6.6 in each contest.
- The Gamecocks get the most three-point shooting production out of Tessa Johnson, who makes 2.1 threes per game.
- The South Carolina steals leader is Edwards, who averages 1.4 takeaways per game, while its blocks leader is Okot, who compiles two rejections per contest.
Louisville Key Players
- Laura Ziegler has tallied 8.2 rebounds and 3.1 assists per game, and is atop the Cardinals leaderboards in those stat categories.
- Tajianna Roberts counts for 13.3 points per game, and is the top scorer on Louisville's team.
- Roberts is the most prolific from deep for the Cardinals, hitting 1.8 threes per game.
- Skylar Jones (2.1 steals per game) is the steal leader for Louisville while Yevheniia Putra (0.6 blocks per game) is the block leader.
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